Lori S. Friedman

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations · Full text

Signaling Pathway, Receptor Tyrosine Kinase, Mapk Pathway +8

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

Teemu T. Junttila, Robert W. Akita, Kathryn L. Parsons et al. · Cancer Cell · 2009 · 822 citations · Full text

Molecular Pharmacology, Signaling Pathway, Medicine +10

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

Annette L. Parks, Kevin R Cook, Marcia Belvin et al. · Nature Genetics · 2004 · 770 citations · Full text

Biology, Drosophila Melanogaster Genome, Genetics +8

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Involvement of Brca2 in DNA Repair

Ketan J. Patel, Veronica Yu, Hyun‐Sook Lee et al. · Molecular Cell · 1998 · 629 citations · Full text

Chromatin, Genome Instability, Dna Damage +4