Kwan Keung Leung

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (PRN1371) for the Treatment of Solid Tumors

Ken A. Brameld, Timothy D. Owens, Erik Verner et al. · Journal of Medicinal Chemistry · 2017 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.

Kwan Keung Leung, Po Sing Leung · PubMed · 2008 · 47 citations

Life Sciences, Biochemistry, Endocrinology +13

Vitamin D and Vitamin A Receptor Expression and the Proliferative Effects of Ligand Activation of These Receptors on the Development of Pancreatic Progenitor Cells Derived from Human Fetal Pancreas

Ka Yan Ng, Man Ting, Kwan Keung Leung et al. · Stem Cell Reviews and Reports · 2010 · 33 citations

Life Sciences, Cell Biology, Developmental Biology +17

The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance

Eleni Venetsanakos, Ken A. Brameld, Vernon T. Phan et al. · Molecular Cancer Therapeutics · 2017 · 28 citations

Medicine, Oncology, Pharmacology +13

Angiotensin II Type 2 Receptor Is Critical for the Development of Human Fetal Pancreatic Progenitor Cells into Islet‐like Cell Clusters and Their Potential for Transplantation

Kwan Keung Leung, Juan Boo Liang, Man Ting et al. · Stem Cells · 2011 · 26 citations · Full text

Life Sciences, Developmental Biology, Endocrinology +15