Jun Yong Choi

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr ⁶⁸² -phosphorylated APP βCTF

Eunju Im, Philip Stavrides, Sandipkumar Darji et al. · Science Advances · 2023 · 73 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors

Jun Yong Choi, Rita Fuerst, Anna M. Knapinska et al. · Journal of Medicinal Chemistry · 2017 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

<i>In Silico</i> HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors

Spencer D. Wood, Wayne Grant, Isabel Adrados et al. · ACS Medicinal Chemistry Letters · 2017 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

Cláudia M. Calvet, Jun Yong Choi, Diane Thomas et al. · PLoS neglected tropical diseases · 2017 · 33 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

Timothy Spicer, Jianwen Jiang, Alexander B. Taylor et al. · Journal of Medicinal Chemistry · 2014 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16