Sandipkumar Darji

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Ying Jiang, Yutaka Sato, Eunju Im et al. · Journal of Neuroscience · 2019 · 178 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease

Anna Pensalfini, Seonil Kim, Shivakumar Subbanna et al. · Cell Reports · 2020 · 129 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Matteo Bordi, Sandipkumar Darji, Yutaka Satō et al. · Cell Death and Disease · 2019 · 122 citations · Full text

Life Sciences, Cell Biology, Genetics +17

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr ⁶⁸² -phosphorylated APP βCTF

Eunju Im, Philip Stavrides, Sandipkumar Darji et al. · Science Advances · 2023 · 73 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

Ying Jiang, John Alam, Stephen N. Gomperts et al. · Nature Communications · 2022 · 60 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17