Thomas E. Hughes

Determinants of the Impaired Secretion of Glucagon-Like Peptide-1 in Type 2 Diabetic Patients

M. Toft-Nielsen, Mette Brimnes Damholt, Sten Madsbad et al. · The Journal of Clinical Endocrinology & Metabolism · 2001 · 840 citations

Medicine, Endocrinology, Physiology +15

1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(<i>S</i>)-pyrrolidine:  A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

Edwin B. Villhauer, J. A. Brinkman, Goli B. Naderi et al. · Journal of Medicinal Chemistry · 2003 · 613 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Sec3p Is a Spatial Landmark for Polarized Secretion in Budding Yeast

Fern P. Finger, Thomas E. Hughes, Peter Novick · Cell · 1998 · 377 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial

Mohammed Farooqui, Janet Valdez, Sabrina Martyr et al. · The Lancet Oncology · 2014 · 366 citations · Full text

Medicine, Immunology, Oncology +11

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

Marju Orho‐Melander, Olle Melander, Candace Guiducci et al. · Diabetes · 2008 · 324 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17