Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

Kaipeng Jing, Kyoungsub Song, Soyeon Shin, +14

Autophagy

Docosahexaenoic AcidMitophagyApoptosisCell DeathPathology +17

Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and cyclooxygenase-2

Kyu Lim, Chang Han, Yifan Dai, +2

Molecular Cancer Therapeutics

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury

Udayan Apte, Sucha Singh, Gang Zeng, +4

American Journal Of Pathology

HepatologyMedicineLiver PhysiologyHepatotoxicityAcetaminophen-induced Injury +4

Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation

Yingjian Wang, Tong Wu, Shi‐Ying Cai, +2

Molecular and Cellular Biology

Tnfr-associated Factor 2ApoptosisImmunologyPathologyCell Death +16

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway

Xuping Yang, Qinhui Liu, Yanping Li, +15

Adipocyte

Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells

Jinhang Zhang, Yanping Li, Qinhui Liu, +15

Hepatology

The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells

Tong Wu, Jing Leng, Chang Han, +1

Molecular Cancer Therapeutics

Fluorescence MicroscopyChemoprevention StrategyOncogenic AgentMedicineInduces Apoptosis +13

Cyclooxygenase-2-derived Prostaglandin E2 Promotes Human Cholangiocarcinoma Cell Growth and Invasion through EP1 Receptor-mediated Activation of the Epidermal Growth Factor Receptor and Akt

Chang Han, Tong Wu

Journal of Biological Chemistry

Pge2 ProductionPge2 SynthesisChemoprevention StrategyPathologyCox-2 Expression +14

Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis

Jiangying Kuang, Yuwei Zhang, Qinhui Liu, +15

Diabetes

Liver-Specific β-Catenin Knockout Mice Exhibit Defective Bile Acid and Cholesterol Homeostasis and Increased Susceptibility to Diet-Induced Steatohepatitis

Jaideep Behari, Tzu-Hsuan Yeh, Lindsay Krauland, +6

American Journal Of Pathology

InflammationMetabolic SyndromeDiet-induced SteatohepatitisHepatologyMedicine +9