Daniel Curtis

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 128 citations · Full text

Genetics, Molecular Biology, Cytoskeleton +16

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions

Daniel Curtis, Aman Sood, Tom J. Phillips et al. · Experimental Neurology · 2014 · 37 citations · Full text

Developmental Biology, Neurophysiology, Brain Development +12

Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

Simone Bonazzi, Carleton P. Goold, Audrey Gray et al. · Journal of Medicinal Chemistry · 2020 · 32 citations · Full text

Integrated Compound Profiling Screens Identify the Mitochondrial Electron Transport Chain as the Molecular Target of the Natural Products Manassantin, Sesquicillin, and Arctigenin

Kevin Lai, Douglas W. Selinger, Jonathan M. Solomon et al. · ACS Chemical Biology · 2012 · 23 citations

Molecular Biology, Natural Products Manassantin, Chemical Biology +19

Antisense Oligonucleotide-Induced Amyloid Precursor Protein Splicing Modulation as a Therapeutic Approach for Dutch-Type Cerebral Amyloid Angiopathy

Elena Daoutsali, Tsinatkeab T. Hailu, Ronald A.M. Buijsen et al. · Nucleic Acid Therapeutics · 2021 · 12 citations · Full text