Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment

Puyu Shi, You-Take Oh, Guojing Zhang, +10

Cancer Letters

Lung Cancer TreatmentSystems BiologyOncogenic AgentMedicineProtein Hyperactivation +7

The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation

Songqing Fan, Yikun Li, Ping Yue, +2

Neoplasia

Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

Yikun Li, Ping Yue, Xingming Deng, +4

Neoplasia

Blocking Lymphocyte Trafficking with FTY720 Prevents Inflammation-Sensitized Hypoxic–Ischemic Brain Injury in Newborns

Dianer Yang, Yu Sun, Siddhartha Kumar Bhaumik, +16

Journal of Neuroscience

The Combination of RAD001 and NVP-BEZ235 Exerts Synergistic Anticancer Activity against Non-Small Cell Lung Cancer In Vitro and In Vivo

Cheng‐Xiong Xu, Yikun Li, Ping Yue, +4

PLoS ONE

ImmunologyMtor Allosteric InhibitorCancer BiologyTumor BiologyMtor-targeted Caner Therapy +14

Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation

Yikun Li, Xuerong Wang, Ping Yue, +8

Journal of Biological Chemistry

Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer

Yikun Li, Songqing Fan, Junghui Koo, +6

Cancer Biology & Therapy

Eif4e SirnaSystems BiologyElevated ExpressionMedicineHuman Nsclc Tissues +10

Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury

Yu Sun, Yikun Li, Bushra Wali, +8

Stroke

cDNA cloning, expression, and mutagenesis of a PR-10 protein SPE-16 from the seeds of Pachyrrhizus erosus

Fang Wu, Ming Yan, Yikun Li, +4

Biochemical and Biophysical Research Communications

BiologyPlant Molecular BiologyBiosynthesisProtein ExpressionPachyrrhizus Erosus +10

A Novel Assay for Protein Phosphatase 2A (PP2A) Complexes In Vivo Reveals Differential Effects of Covalent Modifications on Different <i>Saccharomyces cerevisiae</i> PP2A Heterotrimers

Matthew S. Gentry, Yikun Li, Huijun Wei, +4

Eukaryotic Cell