Xiaofeng Yang

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 461 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy et al. · Nature Chemical Biology · 2017 · 229 citations

Medicine, Cancer Biology, Molecular Biology +8

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

Steven Langston, Stephen Grossman, Dylan B. England et al. · Journal of Medicinal Chemistry · 2021 · 208 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +11

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models

Eric S. Lightcap, Pengfei Yu, Stephen Grossman et al. · Science Translational Medicine · 2021 · 140 citations · Full text

Medicine, Immunology, Oncology +13

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

Michael A. Milhollen, Michael P. Thomas, Usha Narayanan et al. · Cancer Cell · 2012 · 110 citations · Full text

Life Sciences, Genetics, Molecular Biology +7