Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

Zhiyu Peng, Yanbing Cheng, Bertrand Chin‐Ming Tan, +12

Nature Biotechnology

Rna ProcessingNatural SciencesGeneticsRna BiologyMolecular Biology +10

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

Junhui Yu, Shan Li, Jie Qi, +6

Cell Death and Disease

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

Thomas Gaj, Jing Guo, Yoshio Kato, +2

Nature Methods

EngineeringGenome SurgeryGenetic EngineeringMolecular BiologyGene Knockout +5

The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

Han Zhu, Chujin Cao, Zhongcai Wu, +24

Cell Metabolism

ProbioticUrologyMedicineKidney FailureRenal Pathology +6

Directed Evolution of an Enhanced and Highly Efficient FokI Cleavage Domain for Zinc Finger Nucleases

Jing Guo, Thomas Gaj, Carlos F. Barbas

Journal of Molecular Biology

BiochemistryProtein AssemblyNatural SciencesMetalloproteinDirected Evolution +4

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer

Tim Hon Man Chan, Aditi Qamra, Kar Tong Tan, +19

Gastroenterology

OncologyEngineeringMedicinePathologyCancer Genomics +7

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

Jing Guo, Hui Liu, Jie Zheng

Nucleic Acids Research

Drug TargetHit IdentificationMolecular BiologySynthetic Lethality DatabaseSynthetic Lethality +21

A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment

Junhua Li, Huanzi Zhong, Yuliaxis Ramayo‐Caldas, +23

GigaScience

Deficiency of the X-inactivation escaping gene <i>KDM5C</i> in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis

Qian Zheng, Pengfei Li, Xin Zhou, +9

Theranostics

PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide

Tiesuo Zhao, Wei Tian, Jing Guo, +6

Cell Death and Disease