Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi et al. · Science · 2004 · 3.4K citations

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

Luigi Warren, Philip D. Manos, Tim Ahfeldt et al. · Cell stem cell · 2010 · 2.6K citations · Full text

Synthetic Modified Mrna, Induced Pluripotent Stem Cell, Engineering +14

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

Dirk Hockemeyer, Frank Soldner, Caroline Beard et al. · Nature Biotechnology · 2009 · 1.1K citations · Full text

Natural Sciences, Silent Genes, Oligonucleotide +9

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Elena Pérez, Jianbin Wang, Jeffrey C. Miller et al. · Nature Biotechnology · 2008 · 996 citations

Viral Replication, Hiv-1 Resistance, Natural Sciences +12

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

Aron M. Geurts, Gregory J. Cost, Yevgeniy Freyvert et al. · Science · 2009 · 914 citations · Full text