Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Chiara Ambrogio, Gonzalo Goméz-López, Mattia Falcone, +14

Nature Medicine

Tumor BiologyMedicineTherapeutic StrategyKras-driven Lung AdenocarcinomaBronchial Neoplasm +9

Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma

Kristina Y. Aguilera, Huocong Huang, Wenting Du, +10

Molecular Cancer Therapeutics

Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer

Yuanyuan Qiao, Jae Eun Choi, Jean C. Tien, +31

Nature Cancer

Cell AutophagyMitophagyReceptor Tyrosine KinaseImmunologyAutophagy +9

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13

Jianzhang Yang, Yu Chang, Jean C. Tien, +13

Journal of Medicinal Chemistry

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

Zhen Wang, Huan Bian, Sergio G. Bartual, +15

Journal of Medicinal Chemistry

Drug TargetSelective Ddr1 InhibitorsPharmacotherapyChemical BiologyPharmaceutical Chemistry +14

A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB

Yuqi Lin, Qiqi Shi, Guang Yang, +14

Proceedings of the National Academy of Sciences

Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms

Narges K. Tafreshi, Darpan N. Pandya, Christopher J. Tichacek, +11

European Journal of Nuclear Medicine and Molecular Imaging

Endocrine OncologyPreclinical EvaluationMedicinePathologyBronchial Neoplasm +5

Activities of Nerol, a natural plant active ingredient, against Candida albicans in vitro and in vivo

Zhen Wang, Kunlong Yang, Lei Chen, +6

Applied Microbiology and Biotechnology

Antifungal AgentCandida AlbicansMedicineAntifungal AgentsMedicinal Fungi +2

Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson′s disease

Haiyang Yu, Tong Sun, Zhen Wang, +7

Neural Regeneration Research

Microglial PolarizationPeptide SciencePeptide TherapeuticsSynaptic SignalingMolecular Pharmacology +16

Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

Zhen Wang, Yali Zhang, Sergio G. Bartual, +11

ACS Medicinal Chemistry Letters