Jianzhang Yang

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13

Jianzhang Yang, Yu Chang, Jean C. Tien et al. · Journal of Medicinal Chemistry · 2022 · 67 citations · Full text

Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

Jianzhang Yang, Marthandam Asokan Shibu, Lulu Kong et al. · Journal of Medicinal Chemistry · 2019 · 37 citations · Full text

Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide

Yong-Kang Zhang, Jacob J. Plattner, Eric E. Easom et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 23 citations

Bioorganic Chemistry, Biochemistry, Antiparasitic Agent +11

CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13

Jean C. Tien, Jie Luo, Yu Chang et al. · Cell Reports Medicine · 2024 · 22 citations · Full text

Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

Yu Chang, Xiaoju Wang, Jianzhang Yang et al. · Cell Reports Medicine · 2024 · 18 citations · Full text

Immunology, Prostate Cancer Cells, Synthetic Lethality +20