Discovery of a Potent and Specific <i>M. tuberculosis</i> Leucyl-tRNA Synthetase Inhibitor: (<i>S</i>)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[<i>c</i>][1,2]oxaborol-1(3<i>H</i>)-ol (GSK656)

Xianfeng Li, Vincent Hernandez, Fernando Rock, +18

Journal of Medicinal Chemistry

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Andrés Palencia, Xianfeng Li, Wei Bu, +34

Antimicrobial Agents and Chemotherapy

Drug TargetMolecular BiologyAntimicrobial ChemotherapyProtein SynthesisDrug Resistance +16

Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, +14

Bioorganic & Medicinal Chemistry Letters

Novel BenzoxaborolesAntiparasitic AgentMedicineNew ClassChemistry +4

Targeting <i>Toxoplasma gondii</i> <scp>CPSF</scp> 3 as a new approach to control toxoplasmosis

Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, +12

EMBO Molecular Medicine

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Ángel M. Padilla, Wei Wang, Tsutomu Akama, +17

Nature Microbiology

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Yong-Kang Zhang, Jacob J. Plattner, Eric E. Easom, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryAntiparasitic AgentMalariaImmunologyChemistry +16

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, +14

Nature Communications

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntiparasitic AgentMedicineBenzoxaborole Antimalarial AgentsPharmacology +2

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Tsutomu Akama, Yong-Kang Zhang, Yvonne R. Freund, +15

Bioorganic & Medicinal Chemistry Letters

Boron-Pleuromutilins as Anti-<i>Wolbachia</i> Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Robert T. Jacobs, Christopher S. Lunde, Yvonne R. Freund, +31

Journal of Medicinal Chemistry

Medicinal ChemistryAntibioticsAntiparasitic AgentRiver BlindnessWolbachia Load +11