Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan, +12

Nature Medicine

Cancer ImmunosurveillanceT Cell DysfunctionT-regulatory CellImmunologyTumor Immunity +8

Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute

Binbin Wang, Mei Wang, Wubing Zhang, +16

Nature Protocols

Natural SciencesGeneticsMolecular BiologyGenetic EngineeringGenome Engineering +5

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade

Shengqing Gu, Wubing Zhang, Xiaoqing Wang, +30

Cancer Discovery

Integrative analyses of single-cell transcriptome and regulome using MAESTRO

Chenfei Wang, Dongqing Sun, Xin Huang, +13

Genome biology

In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang, Collin Tokheim, Shengqing Gu, +19

Cell

MedicineImmunologyTumor ImmunityVivo Crispr ScreensGene Editing +7

Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD

Sahba Seddighi, Yue Qi, Anna‐Leigh Brown, +48

Science Translational Medicine

GeneticsSplicing VariantCryptic ExonsTranscriptional RegulationDegenerative Pathology +14

Sequence specificity for DNA binding by <i>Escherichia coli</i> SoxS and Rob proteins

Ziyi Li, Bruce Demple

Molecular Microbiology

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, +11

PLoS Biology

Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells

Rongrong Le, Yixin Huang, Yanping Zhang, +25

Cell stem cell

Lineage PlasticityCell LineageDevelopmental BiologyMedicineZscan4-mediated Alternative +8

A highly efficient and stable TiO2@NH2-MIL-125 material for enhanced photocatalytic conversion of CO2 and CH4

Yufei Huang, Wei Ding, Ziyi Li, +5

Separation and Purification Technology