Qi Zhang

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 715 citations · Full text

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

Lynn A. Hyde, Tatiana M. Kazdoba, Mariagrazia Grilli et al. · Behavioural Brain Research · 2005 · 78 citations

Knockout Mouse, Neurodegenerative Diseases, Alzheimer's Disease +7

Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse

Lynn A. Hyde, Nansie A. McHugh, Joseph Chen et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 68 citations

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Mihirbaran Mandal, Zhaoning Zhu, Jared N. Cumming et al. · Journal of Medicinal Chemistry · 2012 · 56 citations · Full text

Combinatorial Chemistry, Bicyclic Iminopyrimidinones, Pseudoaxial Conformation +21

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Theodros Asberom, Zhiqiang Zhao, Thomas Bara et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 31 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +10