Zhaoning Zhu - Concepedia

Author

Zhaoning Zhu

Merck & Co., Inc., Rahway, NJ, USA (United States)

Also Known As

Zhaoning Zhu, Zhu, Zhaoning

Publications

Citations

H-Index

Concepts

All Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)UCB Pharma (Belgium)

About

Zhaoning Zhu is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in medicine, pharmacology, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	12	14	541
2	Biochemistry	11	11	495
3	Natural Sciences	10	10	395
4	Engineering	1	1	10
5	Social Sciences	1	1	98

Zhaoning Zhu

Publications

970

Citations

H-Index

Page 1

	Year	Citations
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryDrug TargetActive Bace1 InhibitorBiochemistryDrug Design	2012	151
Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation Zhaoning Zhu, Z. J. Sun, Yuanzan Ye, Journal of Medicinal Chemistry	2009	120
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction Andrew W. Stamford, Jack D. Scott, Sarah W. Li, ACS Medicinal Chemistry Letters Drug TargetNeurochemical BiomarkersPeptide ScienceSynaptic SignalingPharmaceutical Chemistry	2012	98
Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation Mihirbaran Mandal, Zhaoning Zhu, Jared N. Cumming, Journal of Medicinal Chemistry Combinatorial ChemistryBicyclic IminopyrimidinonesPseudoaxial ConformationPeptide ScienceChemical Biology	2012	56
Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo Z. J. Sun, Theodros Asberom, Thomas Bara, Journal of Medicinal Chemistry	2011	52
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates Mihirbaran Mandal, Yusheng Wu, Jeffrey Misiaszek, Journal of Medicinal Chemistry	2016	41
Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease Xianhai Huang, Wei Zhou, Xiaoxiang Liu, ACS Medicinal Chemistry Letters Neurochemical BiomarkersPharmacotherapyFused Oxadiazine CoreChemical Biologyγ-Secretase Modulators	2012	37
Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators Jun Qin, Wei Zhou, Xianhai Huang, ACS Medicinal Chemistry Letters	2011	34
An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis Alexander Vugler, James P. O’Connell, Mai Ánh Nguyễn, Frontiers in Pharmacology	2022	34
The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators Xianhai Huang, Robert Aslanian, Wei Zhou, ACS Medicinal Chemistry Letters	2010	33

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