Zhaoning Zhu

Statistics

Publications

Citations

994

H-Index

Active since

1998

Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)(Current)

UCB Pharma (Belgium)

Zhaoning Zhu is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in drug discovery, pharmacology, and medicinal chemistry.

Publications per year

1998–2022

Publications

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Jared N. Cumming, Elizabeth M. Smith, Lingyan Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 154 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

Zhaoning Zhu, Z. J. Sun, Yuanzan Ye et al. · Journal of Medicinal Chemistry · 2009 · 121 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Andrew W. Stamford, Jack D. Scott, Sarah W. Li et al. · ACS Medicinal Chemistry Letters · 2012 · 99 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Mihirbaran Mandal, Zhaoning Zhu, Jared N. Cumming et al. · Journal of Medicinal Chemistry · 2012 · 57 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Z. J. Sun, Theodros Asberom, Thomas Bara et al. · Journal of Medicinal Chemistry · 2011 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

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