Fumihito Muro

Discovery of <i>trans</i>-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4<i>S</i>)-methoxy-(2<i>S</i>)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Fumihito Muro, Shin Iimura, Yuuichi Sugimoto et al. · Journal of Medicinal Chemistry · 2009 · 25 citations · Full text

Pharmaceutical Science, Immunology, Orally Active +19

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models

H. Shimizu, Tomonori Yamasaki, Yoshiyuki Yoneda et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 24 citations · Full text

Rheumatology, Anti-inflammatory, Biochemistry +10

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto et al. · Bioorganic & Medicinal Chemistry · 2012 · 23 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Medicine +9

Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency

Mamoru Ohtoyo, Masakazu Tamura, Nobuo Machinaga et al. · Molecular and Cellular Biochemistry · 2014 · 19 citations

Biochemistry, Medicine, Vitamin B6 Deficiency +2

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid

Fumihito Muro, Shin Iimura, Yoshiyuki Yoneda et al. · Bioorganic & Medicinal Chemistry · 2008 · 18 citations · Full text

Medicinal Chemistry, Medicine, Trans-4-substituted Cyclohexanecarboxylic Acid +6