A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Publication | Open Access

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Citations

References

2012

Year

Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe, Fumihito Muro, Yutaka Iigo, Gensuke Takayama, Mika Yokoyama,

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceMedicineMechanism Of ActionPharmacological AgentPharmacotherapyActive Vla-4 AntagonistDrug DevelopmentPharmacologyGood Aqueous SolubilityPharmaceutical ChemistryDrug Discovery