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Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models

H. Shimizu, Tomonori Yamasaki, Yoshiyuki Yoneda, Fumihito Muro, Tomoaki Hamada, Takanori Yasukochi, Shinji Tanaka, Tadashi Toki, Mika Yokoyama, Kaoru Morishita,

Bioorganic & Medicinal Chemistry Letters · 2011 · 24 citations · 21 references

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21

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Joseph A. DiDonato, Makio Hayakawa, David M. Rothwarf et al. · Nature · 1997 · 2.1K citations

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

, , +15

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

Ranjan Sen, David Baltimore · Cell · 1986 · 2K citations

, , +12

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

John Woronicz, Xiong Gao, Zhaodan Cao et al. · Science · 1997 · 1.2K citations

, , +16

How good is fluorine as a hydrogen bond acceptor?

Judith A. K. Howard, Vanessa J. Hoy, David O’Hagan et al. · Tetrahedron · 1996 · 729 citations

, , +9