Leonhard Jakob

The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway

Daniele Hasler, G. Lehmann, Yasuhiro Murakawa et al. · Molecular Cell · 2016 · 130 citations · Full text

Chromatin, Functional Genomics, Lupus +12

The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation

Inga Loedige, Leonhard Jakob, Thomas Treiber et al. · Cell Reports · 2015 · 99 citations · Full text

Crystal Structure, Engineering, Molecular Regulation +17

Biochemical isolation of Argonaute protein complexes by Ago-APP

Judith Hauptmann, Daniel Schraivogel, Astrid Bruckmann et al. · Proceedings of the National Academy of Sciences · 2015 · 95 citations · Full text

Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2

Sarah Willkomm, Leonhard Jakob, Kevin Kramm et al. · Nature Communications · 2022 · 42 citations · Full text

Decoupling the bridge helix of Cas12a results in a reduced trimming activity, increased mismatch sensitivity and impaired conformational transitions

Elisabeth Wörle, Leonhard Jakob, Andreas Schmidbauer et al. · Nucleic Acids Research · 2021 · 31 citations · Full text

Protein Assembly, Trimming Activity, Biomolecular Structure Prediction +21