Judith Hauptmann

Turning catalytically inactive human Argonaute proteins into active slicer enzymes

Judith Hauptmann, Anne Dueck, Simone Harlander et al. · Nature Structural & Molecular Biology · 2013 · 108 citations · Full text

Cellular Enzymology, Biochemistry, Protein Folding +8

Biochemical isolation of Argonaute protein complexes by Ago-APP

Judith Hauptmann, Daniel Schraivogel, Astrid Bruckmann et al. · Proceedings of the National Academy of Sciences · 2015 · 95 citations · Full text

The Slicer Activity of ARGONAUTE1 is Required Specifically for the Phasing, Not Production, of Trans-Acting Short Interfering RNAs in Arabidopsis

Laura Arribas‐Hernández, Antonin Marchais, Christian Peter Poulsen et al. · The Plant Cell · 2016 · 90 citations · Full text

Biology, Duplex Sirna Bound, Transcriptional Regulation +14

Phosphorylation of Argonaute proteins affects <scp>mRNA</scp> binding and is essential for micro <scp>RNA</scp> ‐guided gene silencing <i>in vivo</i>

Miguel Quévillon Huberdeau, Daniela M. Zeitler, Judith Hauptmann et al. · The EMBO Journal · 2017 · 82 citations

Transcriptional Regulation, Signal Transduction, Molecular Regulation +12

Pre-clinical assessment of SLN360, a novel siRNA targeting LPA, developed to address elevated lipoprotein (a) in cardiovascular disease

David A. Rider, Mona Eisermann, Kathrin Löffler et al. · Atherosclerosis · 2022 · 55 citations

Metabolic Syndrome, Cardiovascular Disease, Pharmacology +8