Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- <i>a</i> ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

Nicolas Desroy, Christopher Housseman, Xavier Bock, +27

Journal of Medicinal Chemistry

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis

N. Vandeghinste, Jürgen Klattig, Catherine Jagerschmidt, +16

Journal of Investigative Dermatology

InflammationCytokineAtopic DermatitisMedicineImmune Regulation +7

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

Tobias Puengel, Steve De Vos, Jana Hundertmark, +13

Journal of Clinical Medicine

Liver FibrosisImmunologyPathologyFatty Liver DiseaseMcfa Receptor Gpr84 +18

Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro

Sergio Roman‐Roman, Teresa García, Amanda Jackson, +10

Bone

Developmental BiologyBone Morphogenic ProteinGeneticsBone HomeostasisOsteocalcin +7

Behavior of osteoblast, adipocyte, and myoblast markers in genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro

Teresa García, Sergio Roman‐Roman, Amanda Jackson, +9

Bone

Myoblast MarkersSclerostinFunctional GenomicsDevelopmental BiologyBone Morphogenic Protein +7

Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

Roland Blanqué, L. Lepescheux, Marielle Auberval, +6

BMC Musculoskeletal Disorders

New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas

Pierre Deprez, Taoues Temal, Hélène Jary, +4

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryNatural SciencesOrganic Chemistry +4

Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases

Oscar Mammoliti, Koen Jansen, Sandy El Bkassiny, +31

Journal of Medicinal Chemistry

New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas

Taoues Temal, Hélène Jary, Marielle Auberval, +4

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +7

αvβ3 Antagonists Based on a Central Thiophene Scaffold

Anusch Peyman, K. Scheunemann, David W. Will, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicineCentral Thiophene ScaffoldPharmacologyMolecular Modeling +2