Huw M. Nash

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais et al. · Proceedings of the National Academy of Sciences · 2013 · 661 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

Huw M. Nash, Steven D. Bruner, Orlando D. Schärer et al. · Current Biology · 1996 · 436 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

Rongzhen Lu, Huw M. Nash, Gregory L. Verdine · Current Biology · 1997 · 320 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Kian‐Huat Lim, Han Zhou, Hyun Yong Jeon et al. · Nature Communications · 2020 · 196 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution

Huw M. Nash, Rongzhen Lu, William S. Lane et al. · Chemistry & Biology · 1997 · 172 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +4