Johan Lindström

Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides

Britt‐Marie Swahn, Karin Kolmodin, Sofia Karlström et al. · Journal of Medicinal Chemistry · 2012 · 98 citations · Full text

New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain

Ylva Gravenfors, Jenny Viklund, Jan Blid et al. · Journal of Medicinal Chemistry · 2012 · 65 citations · Full text

New Aminoimidazoles, Neurochemical Biomarkers, Pharmaceutical Chemistry +23

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target

Manuel Ellermann, Ashley Eheim, Fredrik Rahm et al. · ACS Chemical Biology · 2017 · 57 citations · Full text

Broad-spectrum Cancer Target, Cancer Dependency, Present Bay-707 +12

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Britt‐Marie Swahn, Jörg Holenz, Jacob Kihlström et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 48 citations · Full text

Medicine, Pharmacology, Bace-1 Inhibitors +10

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design

Fredrik Rahm, Jenny Viklund, L. Tresaugues et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text