Ashley Eheim

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

David B. Sykes, Youmna Kfoury, François Mercier et al. · Cell · 2016 · 468 citations · Full text

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

John K. Eaton, Laura Furst, Richard A. Ruberto et al. · Nature Chemical Biology · 2020 · 445 citations · Full text

Selective Covalent Targeting, Organometallic Electrochemistry, Chemistry +1

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

Sven Christian, Claudia Merz, Laura Evans et al. · Leukemia · 2019 · 232 citations · Full text

Mixed-phenotype Acute Leukemia, Genetics, Pathology +17

Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance

Maria Quanz, Eckhard Bender, Charlotte Kopitz et al. · Molecular Cancer Therapeutics · 2018 · 106 citations · Full text

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target

Manuel Ellermann, Ashley Eheim, Fredrik Rahm et al. · ACS Chemical Biology · 2017 · 57 citations · Full text

Broad-spectrum Cancer Target, Cancer Dependency, Present Bay-707 +12