Manuel Ellermann

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target

Manuel Ellermann, Ashley Eheim, Fredrik Rahm et al. · ACS Chemical Biology · 2017 · 57 citations · Full text

Broad-spectrum Cancer Target, Cancer Dependency, Present Bay-707 +12

Molecular Recognition at the Active Site of Catechol‐<i>O</i>‐Methyltransferase: Energetically Favorable Replacement of a Water Molecule Imported by a Bisubstrate Inhibitor

Manuel Ellermann, Roland Jakob‐Roetne, C. Lerner et al. · Angewandte Chemie International Edition · 2009 · 40 citations · Full text

Molecular Recognition at the Active Site of Catechol‐<i>O</i>‐methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors

Manuel Ellermann, Ralph Paulini, Roland Jakob‐Roetne et al. · Chemistry - A European Journal · 2011 · 35 citations

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design

Fredrik Rahm, Jenny Viklund, L. Tresaugues et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text

Catechol-<i>O</i>-methyltransferase in complex with substituted 3′-deoxyribose bisubstrate inhibitors

Manuel Ellermann, C. Lerner, Guillaume Burgy et al. · Acta Crystallographica Section D Biological Crystallography · 2012 · 29 citations