Roland Jakob‐Roetne

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Christoph Patsch, Ludivine Challet-Meylan, Eva Thoma et al. · Nature Cell Biology · 2015 · 626 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +14

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

Mark B. Pepys, J. Herbert, W. L. Hutchinson et al. · Nature · 2002 · 545 citations

Medicine, Pharmacology, Pharmacotherapy +13

Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder

Patrick Schnider, Caterina Bissantz, Andreas Bruns et al. · Journal of Medicinal Chemistry · 2020 · 64 citations

Medicine, Pharmacokinetics, Pharmacology +12

X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing.

C. Lerner, A. Ruf, Völker Gramlich et al. · Angewandte Chemie International Edition · 2001 · 63 citations

Life Sciences, Biochemistry, Pharmacology +15

Structure-Based Design, Synthesis, and in vitro Evaluation of Bisubstrate Inhibitors for CatecholO-Methyltransferase (COMT)

B. Masjost, Patrick Ballmer, Edilio Borroni et al. · Chemistry - A European Journal · 2000 · 60 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +16