C. Lerner - Concepedia

Author

C. Lerner

Also Known As

C. D. Lerner, C. Lerner, Christian D. Lerner, Christian Lerner, Lerner, C., Lerner, C.D., Lerner, Christian, Lerner, Christian Daniel

Publications

1.3K

Citations

H-Index

Concepts

All Affiliations

Roche (Switzerland)ETH Zurich Harvard University Board of the Swiss Federal Institutes of Technology

About

C. Lerner is an author at Roche (Switzerland) specializing in drug discovery, medicine, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	10	10	505
2	Natural Sciences	10	10	721
3	Biochemistry	10	10	721
4	Chemical Biology	6	6	218
5	Engineering	1	1	294

C. Lerner

Publications

1.2K

Citations

H-Index

Page 1

	Year	Citations
A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics Mark G. Charest, C. Lerner, Jason D. Brubaker, Science Enantioselective SynthesisBioorganic ChemistryEngineeringBiochemistryIsolated Natural Products	2005	294
A Robust Platform for the Synthesis of New Tetracycline Antibiotics Cuixiang Sun, Qiu Wang, Jason D. Brubaker, Journal of the American Chemical Society	2008	128
A Real-World Perspective on Molecular Design Bernd Kuhn, Wolfgang Guba, Jérôme Hert, Journal of Medicinal Chemistry Drug TargetHit IdentificationMolecular BiologyComputational ChemistryRoche Research Projects	2016	119
Machine learning-powered antibiotics phenotypic drug discovery Sannah Zoffmann, Maarten Vercruysse, Fethallah Benmansour, Scientific Reports	2019	107
Safety screening in early drug discovery: An optimized assay panel Stefanie Bendels, Caterina Bissantz, Bernhard Fasching, Journal of Pharmacological and Toxicological Methods Drug SafetyPredictive ToxicologyPreclinical Drug EvaluationBioanalysisPharmacology	2019	78
Synthesis of Novel Nonpeptidic Thrombin Inhibitors U. Obst, P. Betschmann, C. Lerner, Helvetica Chimica Acta Peptide SciencePharmacotherapyChemical BiologyPharmaceutical ChemistryThrombosis	2000	69
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. C. Lerner, A. Ruf, Völker Gramlich, Angewandte Chemie International Edition Binding AffinityMolecular BiologyEnzyme PurificationS DiseaseMolecular Pharmacology	2001	62
Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity C. Lerner, B. Masjost, A. Ruf, Organic & Biomolecular Chemistry Bioorganic ChemistryBisubstrate InhibitorsChemical BiologyMedicinal ChemistryEnzyme Catechol-o-methyltransferase	2002	57
A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity <i>In Vitro</i> Jeremy C. Jones, Bindumadhav M. Marathe, C. Lerner, Antimicrobial Agents and Chemotherapy	2016	52
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity C. Lerner, A. Ruf, Völker Gramlich, Angewandte Chemie	2001	51

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