Nienke A. de Vries

P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan

Nienke A. de Vries, Jin Zhao, Emily Kroon et al. · Clinical Cancer Research · 2007 · 267 citations

Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in<i>in vitro</i>and<i>in vivo</i>pharmacokinetic studies employing Bcrp1−/−/Mdr1a/1b−/− (triple-knockout) and wild-type mice

Serena Marchetti, Nienke A. de Vries, Tessa Buckle et al. · Molecular Cancer Therapeutics · 2008 · 199 citations

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP

Nienke A. de Vries, Tessa Buckle, Jin Zhao et al. · Investigational New Drugs · 2010 · 154 citations

Medicine, Receptor Tyrosine Kinase, Brain Penetration +7

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2

Mark C. de Gooijer, Nienke A. de Vries, Tessa Buckle et al. · Neoplasia · 2018 · 125 citations · Full text

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

Nienke A. de Vries, Danielle Hulsman, Waseem Akhtar et al. · Cell Reports · 2015 · 88 citations · Full text

Ezh2 Activity, High-grade Gliomas, Cancer Biology +17