<i>Ink4a</i> and <i>Arf</i> differentially affect cell proliferation and neural stem cell self-renewal in <i>Bmi1</i>-deficient mice

Sophia W.M. Bruggeman, Merel E. Valk-Lingbeek, Petra P.M. van der Stoop, +8

Genes & Development

Bmi1 Controls Tumor Development in an Ink4a/Arf-Independent Manner in a Mouse Model for Glioma

Sophia W.M. Bruggeman, Danielle Hulsman, Ellen Tanger, +5

Cancer Cell

Tumor BiologyDevelopmental BiologyGliomaMedicineInk4a/arf-independent Manner +7

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

Anders H. Lund, Geoffrey Turner, Alla Trubetskoy, +7

Nature Genetics

Genome InstabilityCdkn2a-deficient MiceMedicineImmunologyCancer Genomics +5

In Vivo RNAi Screen for BMI1 Targets Identifies TGF-β/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis

Gaetano Gargiulo, Matteo Cesaroni, Michela Serresi, +5

Cancer Cell

Neuro-oncologyDevelopmental BiologyCell RegulationGliomaMedicine +7

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer

Michela Serresi, Gaetano Gargiulo, Natalie Proost, +9

Cancer Cell

Epithelial-mesenchymal TransitionNon-small-cell Lung CancerLung InflammationMedicineImmunology +7

Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells

Petra van der Stoop, Erwin Boutsma, Danielle Hulsman, +6

PLoS ONE

The chromodomain helicase Chd4 is required for Polycomb‐mediated inhibition of astroglial differentiation

Anke Sparmann, Yunli Xie, Els Verhoeven, +7

The EMBO Journal

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

Nienke A. de Vries, Danielle Hulsman, Waseem Akhtar, +6

Cell Reports

Ezh2 ActivityHigh-grade GliomasCancer BiologyGliomaTumor Biology +15

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

Cesare Lancini, Paul C.M. van den Berk, Joseph H.A. Vissers, +10

The Journal of Experimental Medicine

Histone UbiquitinationEpigenetic ChangeCell CycleEpigeneticsTranscriptional Regulation +23

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition

Michela Serresi, Sonia Kertalli, Lifei Li, +5

Science Advances

Emt DriverEpigeneticsEmt InterconversionTumor BiologyEpithelial-mesenchymal Transition +20