A. Podjarny

Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA ^Asp

Marc Ruff, Sriram Krishnaswamy, Marcel Boeglin et al. · Science · 1991 · 637 citations

Life Sciences, Biochemistry, Molecular Biology +15

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Denise Martinez-Zapien, Francesc X. Ruiz, Juline Poirson et al. · Nature · 2016 · 487 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å

Eduardo Howard, Ruslan Sanishvili, Raúl E. Cachau et al. · Proteins Structure Function and Bioinformatics · 2004 · 313 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +14

A ‘specificity’ pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil

Alexandre Urzhumtsev, F. Favier, A. Mitschler et al. · Structure · 1997 · 232 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-<i>N</i>-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications

M.C. Van Zandt, Michael L. Jones, David Gunn et al. · Journal of Medicinal Chemistry · 2005 · 226 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16