Therina du Toit

11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

Amanda C. Swart, Lindie Schloms, Karl‐Heinz Storbeck et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 119 citations

Life Sciences, Biochemistry, Endocrinology +14

Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone

Therina du Toit, Liezl M. Bloem, Jonathan L. Quanson et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2016 · 66 citations

Life Sciences, Biochemistry, Oncology +16

Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry

Thomas Andrieu, Therina du Toit, Bruno Vogt et al. · Analytical and Bioanalytical Chemistry · 2022 · 42 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

Rachelle Gent, Therina du Toit, Liezl M. Bloem et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 41 citations

Life Sciences, Biochemistry, Enzymology +13

Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

Therina du Toit, Amanda C. Swart · Molecular and Cellular Endocrinology · 2017 · 34 citations

Life Sciences, Biochemistry, Oncology +16