Michael Mrosek

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Aldo-keto Reductase, Molecular Biology, Lead Identification +19

Molecular determinants for the recruitment of the ubiquitin‐ligase MuRF‐1 onto M‐line titin

Michael Mrosek, D. Labeit, Stephanie H. Witt et al. · The FASEB Journal · 2007 · 95 citations

Crystal Structure, Molecular Regulation, Molecular Biology +24

Fragment Screening by Weak Affinity Chromatography: Comparison with Established Techniques for Screening against HSP90

Elinor Meiby, Heather Simmonite, Loic Le Strat et al. · Analytical Chemistry · 2013 · 59 citations

Hit Identification, Hsp90 Wac Columns, Fragment-based Lead Discovery +26

Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging

Gaeun Park, Sohee Baek, Jong‐Eun Kim et al. · Biochemical Pharmacology · 2015 · 52 citations

Uvb-induced Skin Photoaging, Medicine, Photocarcinogenesis +5

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site

Jianbin Zheng, Long Chen, Owen S. Skinner et al. · Journal of the American Chemical Society · 2018 · 47 citations · Full text

Crystal Structure, Proteinlipid Interaction, Gcase Dimerization +15