Sachio Shibata

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility

Tomohiro Ohashi, Yuya Oguro, Toshio Tanaka et al. · Bioorganic & Medicinal Chemistry · 2012 · 71 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Active Hedgehog +13

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

Kenichi Iwai, Tadahiro Nambu, Ryo Dairiki et al. · Science Advances · 2019 · 67 citations · Full text

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors

Tomohiro Ohashi, Yuya Oguro, Toshio Tanaka et al. · Bioorganic & Medicinal Chemistry · 2012 · 64 citations · Full text

Medicinal Chemistry, Medicine, Novel Hedgehog +4

Identification of the first highly selective inhibitor of human lactate dehydrogenase B

Sachio Shibata, Satoshi Sogabe, Masanori Miwa et al. · Scientific Reports · 2021 · 54 citations · Full text

CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens

Tsuyoshi Ishii, Takuro Okai, Misa Iwatani-Yoshihara et al. · Scientific Reports · 2017 · 49 citations · Full text