Jenny Wen

Discovery of Sodium <i>R</i>-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Chen Chen, Dongpei Wu, Zhiqiang Guo et al. · Journal of Medicinal Chemistry · 2008 · 119 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

A Thienopyridazinone-Based Melanin-Concentrating Hormone Receptor 1 Antagonist with Potent in Vivo Anorectic Properties

Brian Dyck, Stacy Markison, Liren Zhao et al. · Journal of Medicinal Chemistry · 2006 · 43 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +8

Identification of Novel, Water-Soluble, 2-Amino-<i>N</i>-pyrimidin-4-yl Acetamides as A_2AReceptor Antagonists with In Vivo Efficacy

Deborah H. Slee, Xiaohu Zhang, M. N. Moorjani et al. · Journal of Medicinal Chemistry · 2008 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A_2AAdenosine Receptor Antagonists for the Treatment of Parkinson’s Disease

Xiaohu Zhang, John E. Tellew, Zhiyong Luo et al. · Journal of Medicinal Chemistry · 2008 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

4-{(<i>2R</i>)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a Potent and Selective Melanocortin-4 Receptor AntagonistDesign, Synthesis, and Characterization

Chen Chen, Joseph Pontillo, Beth A. Fleck et al. · Journal of Medicinal Chemistry · 2004 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15