Joseph Pontillo

Discovery of Sodium <i>R</i>-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Chen Chen, Dongpei Wu, Zhiqiang Guo et al. · Journal of Medicinal Chemistry · 2008 · 117 citations · Full text

Novel Uracil Phenylethylamines, Gynecology, Pharmacotherapy +16

Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor

Joseph Pontillo, Zhiqiang Guo, Dongpei Wu et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 32 citations

Gonadotropin-releasing Hormone Receptor, Hormonal Receptor, Medicine +2

Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines

Fábio C. Tucci, Nicole S. White, Stacy Markison et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 32 citations

Human Melanocortin-4 Receptor, Biochemistry, Functional Selectivity +7

4-{(<i>2R</i>)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a Potent and Selective Melanocortin-4 Receptor AntagonistDesign, Synthesis, and Characterization

Chen Chen, Joseph Pontillo, Beth A. Fleck et al. · Journal of Medicinal Chemistry · 2004 · 31 citations · Full text

Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor

Joseph Pontillo, Joseph A. Tran, Beth A. Fleck et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 26 citations · Full text

Human Melanocortin-4 Receptor, Biochemistry, Functional Selectivity +8