Edward L. Conn

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Matthew F. Calabrese, Francis Rajamohan, Melissa S. Harris et al. · Structure · 2014 · 179 citations · Full text

Opposite Poles, Molecular Physiology, Signal Transduction +9

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar et al. · Journal of Medicinal Chemistry · 2016 · 115 citations · Full text

Renal Inflammation, Pharmacotherapy, Insulin Signaling +19

Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging

Steven H. Liang, Jinshan Michael Chen, Marc D. Normandin et al. · Angewandte Chemie International Edition · 2016 · 90 citations · Full text

A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-<i>H</i>-pyridazin-3-one

Banavara L. Mylari, Sandra J. Armento, David A. Beebe et al. · Journal of Medicinal Chemistry · 2003 · 68 citations · Full text

Oral Bioavailability, Aldo-keto Reductase, Glycobiology +17

A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2<i>H</i>-pyridazin-3-one and Congeners

Banavara L. Mylari, Sandra J. Armento, David A. Beebe et al. · Journal of Medicinal Chemistry · 2005 · 65 citations · Full text

Medicinal Chemistry, Aldo-keto Reductase, Biochemistry +15