Anna Garbelli

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

Annalaura Brai, Roberta Fazi, Cristina Tintori et al. · Proceedings of the National Academy of Sciences · 2016 · 112 citations · Full text

Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

Giovanni Maga, Federico Falchi, Marco Radi et al. · ChemMedChem · 2011 · 105 citations

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

Roberta Fazi, Cristina Tintori, Annalaura Brai et al. · Journal of Chemical Information and Modeling · 2015 · 96 citations

Viral Replication, Hit Identification, Synthetic Virology +22

A Motif Unique to the Human Dead-Box Protein DDX3 Is Important for Nucleic Acid Binding, ATP Hydrolysis, RNA/DNA Unwinding and HIV-1 Replication

Anna Garbelli, Sandra Beermann, Giulia di Cicco et al. · PLoS ONE · 2011 · 88 citations · Full text

Viral Replication, Immunology, Molecular Biology +16

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

Marco Radi, Federico Falchi, Anna Garbelli et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 87 citations · Full text

Natural Sciences, Human Retrovirus, Immunology +10