Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

Giovanni Maga, Federico Falchi, Marco Radi, +16

ChemMedChem

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

Marco Radi, Federico Falchi, Anna Garbelli, +8

Bioorganic & Medicinal Chemistry Letters

Natural SciencesHuman RetrovirusImmunologyAntiviral Drug DevelopmentMolecular Biology +8

Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3

Giovanni Maga, Federico Falchi, Anna Garbelli, +4

Journal of Medicinal Chemistry

Viral ReplicationMolecular BiologyAntiviral DrugMolecular Docking CalculationsMolecular Pharmacology +17

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

Elvira Sondo, Federico Falchi, Emanuela Caci, +10

Cell chemical biology

FibrosisMolecular PhysiologyPathologyPulmonary PharmacologyPulmonary Fibrosis +4

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

Marco Radi, Emmanuele Crespan, Giorgia Botta, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +7

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile

Federica Prati, Christian Bergamini, Marı́a Teresa Molina, +6

Journal of Medicinal Chemistry

Medicinal ChemistryLeishmania DonovaniPharmaceutical ChemistryHealth SciencesBiochemistry +12

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification

Federico Falchi, Sine Mandrup Bertozzi, Giuliana Ottonello, +9

Analytical Chemistry

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells

Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, +14

European Journal of Medicinal Chemistry

Pancreatic CancerMedicineHomologous RecombinationCancer Cell BiologyPancreatic Cancer Cells +7

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

Greta Bagnolini, Domenico Milano, Marcella Manerba, +16

Journal of Medicinal Chemistry

<i>N</i>‐[2‐Methyl‐5‐(triazol‐1‐yl)phenyl]pyrimidin‐2‐amine as a Scaffold for the Synthesis of Inhibitors of Bcr‐Abl

Federica Arioli, Stella Borrelli, F. Colombo, +10

ChemMedChem