Federico Falchi

Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

Giovanni Maga, Federico Falchi, Marco Radi et al. · ChemMedChem · 2011 · 105 citations

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

Marco Radi, Federico Falchi, Anna Garbelli et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 87 citations · Full text

Natural Sciences, Human Retrovirus, Immunology +10

Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3

Giovanni Maga, Federico Falchi, Anna Garbelli et al. · Journal of Medicinal Chemistry · 2008 · 83 citations · Full text

Viral Replication, Molecular Biology, Antiviral Drug +19

Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

Elvira Sondo, Federico Falchi, Emanuela Caci et al. · Cell chemical biology · 2018 · 72 citations · Full text

Fibrosis, Molecular Physiology, Pathology +6

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

Marco Radi, Emmanuele Crespan, Giorgia Botta et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 56 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +9