Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure−Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors

Serena Pasquini, Claudia Mugnaini, Cristina Tintori, +9

Journal of Medicinal Chemistry

4-Quinolone-3-carboxylic Acid MotifChemistryAntiviral DrugHuman Immunodeficiency VirusMedicinal Chemistry +15

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

Annalaura Brai, Roberta Fazi, Cristina Tintori, +15

Proceedings of the National Academy of Sciences

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

Roberta Fazi, Cristina Tintori, Annalaura Brai, +5

Journal of Chemical Information and Modeling

Viral ReplicationHit IdentificationSynthetic VirologyMolecular BiologyViral Structural Protein +20

Pyrazolo[3,4-<i>d</i>]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation

Fabio Carraro, Antonella Naldini, Annalisa Pucci, +14

Journal of Medicinal Chemistry

ApoptosisCell DeathCellular PharmacologyCell ProliferationChemical Biology +18

Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-<i>d</i>]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study

Marco Radi, Elena Dreassi, Chiara Brullo, +13

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryLead 1PharmacotherapyChemical Biology +16

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling

Alessandro Furlan, F. Colombo, Andrea Kövér, +15

European Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicine +9

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

Silvia Schenone, Chiara Brullo, Olga Bruno, +8

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +7

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors

Suvi Rajamäki, Anna Innitzer, Chiara Falciani, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineAntiviral Drug DevelopmentAntiviral TherapyNovel Thiobarbituric Acid- +8

Targets Looking for Drugs: A Multistep Computational Protocol for the Development of Structure-Based Pharmacophores and Their Applications for Hit Discovery

Cristina Tintori, Valentina Corradi, Matteo Magnani, +2

Journal of Chemical Information and Modeling

Antiproliferative and proapoptotic activities of new pyrazolo[3,4‐ <i>d</i> ]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

Adriano Spreafico, Silvia Schenone, Tommaso Serchi, +11

The FASEB Journal