Yukun Guan

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv, Meixia Chen, Rui Zhang et al. · Cell Research · 2020 · 927 citations · Full text

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Chenguang Wang, Yukun Guan, Mengze Lv et al. · Immunity · 2018 · 739 citations · Full text

Chromatin, Double-stranded Dna, Nucleic Acid Chemistry +13

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

Huihui Chen, Hui Sun, Fuping You et al. · Cell · 2011 · 368 citations

Inflammation, Antiviral Innate Immunity, Allergy +12

Manganese salts function as potent adjuvants

Rui Zhang, Chenguang Wang, Yukun Guan et al. · Cellular and Molecular Immunology · 2021 · 300 citations · Full text

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

Zhen Zhao, Zhixing Ma, Bo Wang et al. · Cell Reports · 2020 · 288 citations · Full text