Yukun Guan

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv, Meixia Chen, Rui Zhang et al. · Cell Research · 2020 · 1K citations · Full text

Life Sciences, Immunology, Oncology +17

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Chenguang Wang, Yukun Guan, Mengze Lv et al. · Immunity · 2018 · 814 citations · Full text

Life Sciences, Microbiology, Molecular Biology +13

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

Huihui Chen, Hui Sun, Fuping You et al. · Cell · 2011 · 373 citations

Life Sciences, Immunology, Cell Signaling +13

Manganese salts function as potent adjuvants

Rui Zhang, Chenguang Wang, Yukun Guan et al. · Cellular and Molecular Immunology · 2021 · 324 citations · Full text

Life Sciences, Immunology, Nutrition +15

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

Zhen Zhao, Zhixing Ma, Bo Wang et al. · Cell Reports · 2020 · 313 citations · Full text

Life Sciences, Chemistry, Molecular Biology +17