Bradley Brasher

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 346 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +13

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

Bradley Brasher, Richard A. Van Etten · Journal of Biological Chemistry · 2000 · 274 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop

S. A. Roumiantsev, Neil P. Shah, M. Gorre et al. · Proceedings of the National Academy of Sciences · 2002 · 258 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling

Shaoguang Li, Anthony D. Couvillon, Bradley Brasher et al. · The EMBO Journal · 2001 · 104 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

Pengda Liu, Wenjian Gan, Siyuan Su et al. · Science Signaling · 2018 · 102 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15