Telomere dysfunction induces metabolic and mitochondrial compromise

Ergün Sahin, Simona Colla, Marc Liesa, +27

Nature

Mitochondrial FunctionGeneticsPhysiologyMetabolismMedicine +2

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Mariela Jaskelioff, Florian L. Müller, Ji-Hye Paik, +10

Nature

Telomerase ReactivationAgingLongevityCellular SenescenceMedicine +2

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

Gregory R. Hoffman, Rami Rahal, Frank P. Buxton, +24

Proceedings of the National Academy of Sciences

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

Jian Hu, Soyoon Hwang, Marc Liesa, +15

Cell

MedicinePathologyCancer BiologyMitochondrial Adaptive MechanismsAnti-cancer Agent +5

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

Zhihu Ding, Chang‐Jiun Wu, Mariela Jaskelioff, +21

Cell

UrologyTelomerase ReactivationMedicineBone MetastasesProstatic Disease +3

Rad54p Is a Chromatin Remodeling Enzyme Required for Heteroduplex DNA Joint Formation with Chromatin

Mariela Jaskelioff, Stephen Van Komen, Jocelyn E. Krebs, +2

Journal of Biological Chemistry

Dna Double-strand BreaksGeneticsMolecular BiologyYeast Rad51pMolecular Genetics +16

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

Kenneth L. Scott, Cristina Nogueira, Timothy P. Heffernan, +19

Cancer Cell

MedicineProinvasion Metastasis DriversMelanomaPathologyCancer Biology +1

SWI-SNF-Mediated Nucleosome Remodeling: Role of Histone Octamer Mobility in the Persistence of the Remodeled State

Mariela Jaskelioff, Igor M. Gavin, Craig L. Peterson, +1

Molecular and Cellular Biology

LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors

Kelli‐Ann Monaco, Scott Delach, Jing Yuan, +24

Clinical Cancer Research

Chromatin and transcription: histones continue to make their marks

Mariela Jaskelioff, Craig L. Peterson

Nature Cell Biology

Histone ModificationsChromatinChromatin StructureChromatin RemodelingMedicine +10