Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis, +28

Cell

Pancreatic CancerOncogenic AgentMedicineAnabolic Glucose MetabolismPathology +5

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Qianghu Wang, Baoli Hu, Xin Hu, +31

Cancer Cell

Neuro-oncologyGliomaTumor HeterogeneityImmunologyTumor Immunity +8

Systematic analysis of telomere length and somatic alterations in 31 cancer types

Floris P Barthel, Wei Wei, Ming Tang, +12

Nature Genetics

Somatic VariantTumor HeterogeneityMedicineGeneticsSystematic Analysis +7

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

Hoon Kim, Siyuan Zheng, Seyed S. Amini, +20

Genome Research

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

Boyi Gan, Jian Hu, Shan Jiang, +8

Nature

Developmental BiologyCell RegulationCell DivisionMedicineStem Cell Mobilization +8

Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance

Yanshuo Chu, Enyu Dai, Yating Li, +42

Nature Medicine

Cancer ImmunosurveillanceT-regulatory CellImmunologyTumor ImmunityImmunoediting +8

Passenger deletions generate therapeutic vulnerabilities in cancer

Florian L. Müller, Simona Colla, Elisa Aquilanti, +19

Nature

OncologyPassenger DeletionsCancer TreatmentMedicineCancer Research +1

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

Jian Hu, Soyoon Hwang, Marc Liesa, +15

Cell

MedicinePathologyCancer BiologyMitochondrial Adaptive MechanismsAnti-cancer Agent +5

PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas

Hongwu Zheng, Haoqiang Ying, Ruprecht Wiedemeyer, +17

Cancer Cell

Induced Pluripotent Stem CellDevelopmental BiologySignaling PathwayGliomaMedicine +9

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

Baoli Hu, Qianghu Wang, Yanru Wang, +30

Cell

Lineage PlasticityDevelopmental BiologyInvasive GrowthMedicineEpigenetic Activation +8