Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

Chetan Ahire, Ádám Nyúl‐Tóth, Jordan DelFavero, +17

Aging Cell

Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain

Rafał Gulej, Ádám Nyúl‐Tóth, Chetan Ahire, +15

GeroScience

Neuro-oncologyHealth SciencesGliomaCell DeathMouse Brain +8

Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

Tamás Kiss, Ádám Nyúl‐Tóth, Jordan DelFavero, +11

GeroScience

InflammationBrain FunctionMedicineCortical RemodelingWhite Matter +7

Age‐related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging

Andriy Yabluchanskiy, Ádám Nyúl‐Tóth, Anna Csiszár, +8

Psychophysiology

AgingCerebral Vascular RegulationNeurovascular DiseaseAlzheimer's DiseaseAnimal Models +18

Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors

Rafał Gulej, Ádám Nyúl‐Tóth, Boglárka Csík, +11

GeroScience

InflammationAgingYoung Blood FactorsMedicineImmunology +11

Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling

Tamás Kiss, Ádám Nyúl‐Tóth, Rafał Gulej, +13

GeroScience

Developmental BiologyAgingLongevityVascular AdaptationPhysiology +9

Molecular changes associated with spinal cord aging

Katarzyna M. Piekarz, Shylesh Bhaskaran, Kavithalakshmi Sataranatarajan, +11

GeroScience

Degenerative SpineSpinal Cord InjuryAgingLongevityCellular Senescence +3

Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax

Janet Faakye, Ádám Nyúl‐Tóth, Mihaly Muranyi, +12

GeroScience

AgingLongevityMedicineNovel ApproachCell Death +9

Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model

Rheal A. Towner, Rafał Gulej, Michelle Zalles, +5

GeroScience

InflammationTranslational MedicineAnti-inflammatoryMedicineAutophagy +11

Endothelial deficiency of insulin‐like growth factor‐1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype

Rafał Gulej, Boglárka Csík, Janet Faakye, +9

Microcirculation