Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

Stefano Tarantini, Marta Noa Valcarcel‐Ares, Péter Tóth, +12

Redox Biology

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

Tamás Kiss, Ádám Nyúl‐Tóth, Priya Balasubramanian, +10

GeroScience

Single Cell SequencingMedicineDegenerative PathologyCellular SenescenceVascular Biology +6

Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype

Stefano Tarantini, Marta Noa Valcarcel‐Ares, Andriy Yabluchanskiy, +13

The Journals of Gerontology Series A

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

Gábor Fülöp, Tamás Kiss, Stefano Tarantini, +6

GeroScience

InflammationNrf2 DeficiencyAgingLongevityCerebrovascular Inflammation +11

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Tamás Kiss, Ádám Nyúl‐Tóth, Priya Balasubramanian, +9

GeroScience

Mitochondrial ProtectionLifespan ExtensionNeurodegenerative DiseasesNicotinamide MononucleotideMedicine +12

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment

Tamás Kiss, Priya Balasubramanian, Marta Noa Valcarcel‐Ares, +10

GeroScience

Nicotinamide MononucleotideMedicineEndothelial DysfunctionVascular Cognitive ImpairmentVascular Biology +9

Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms

Zsuzsanna Helyes, Valéria Tékus, Nikolett Szentes, +13

Proceedings of the National Academy of Sciences

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

Andriy Yabluchanskiy, Stefano Tarantini, Priya Balasubramanian, +12

GeroScience

Neurodegenerative DiseasesNeurophysiologySynaptic TransmissionGenetic DepletionNeurovascular Coupling Responses +10

Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline

Marta Noa Valcarcel‐Ares, Zsuzsanna Tucsek, Tamás Kiss, +13

The Journals of Gerontology Series A

AgingStructural PlasticityOxidative StressNeuroinflammationObesity +14

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Tamás Kiss, Cory B. Giles, Stefano Tarantini, +11

GeroScience

Nicotinamide MononucleotideAnti-agingAgingLongevityPhysiology +12