Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

Tamás Kiss, Ádám Nyúl‐Tóth, Priya Balasubramanian, +10

GeroScience

Single Cell SequencingMedicineDegenerative PathologyCellular SenescenceVascular Biology +6

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

Andriy Yabluchanskiy, Stefano Tarantini, Priya Balasubramanian, +12

GeroScience

Neurodegenerative DiseasesNeurophysiologySynaptic TransmissionGenetic DepletionNeurovascular Coupling Responses +10

Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging

Stefano Tarantini, Andriy Yabluchanskiy, Tamás Csípő, +12

GeroScience

Alzheimer's DiseaseAgingLongevityDementiaPhysiology +11

Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice

Stefano Tarantini, Priya Balasubramanian, Jordan DelFavero, +11

GeroScience

HematologyPharmacologyCell DeathAged MicePharmacotherapy +3

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

Chetan Ahire, Ádám Nyúl‐Tóth, Jordan DelFavero, +17

Aging Cell

Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography

Ádám Nyúl‐Tóth, Stefano Tarantini, Jordan DelFavero, +13

American Journal of Physiology-Heart and Circulatory Physiology

Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain

Rafał Gulej, Ádám Nyúl‐Tóth, Chetan Ahire, +15

GeroScience

Neuro-oncologyHealth SciencesGliomaCell DeathMouse Brain +8

Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia

Priya Balasubramanian, Jordan DelFavero, Anna Ungvari, +5

Ageing Research Reviews

NutritionAlzheimer's DiseaseAgingGeriatricsVascular Cognitive Disorder +8

Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

Tamás Kiss, Ádám Nyúl‐Tóth, Jordan DelFavero, +11

GeroScience

InflammationBrain FunctionMedicineCortical RemodelingWhite Matter +7

Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer’s disease

Ádám Nyúl‐Tóth, Jordan DelFavero, Péter Mukli, +6

GeroScience

Gait AnalysisNeurodegenerative DiseasesAlzheimer's DiseaseTg2576 Mouse ModelDegenerative Pathology +7