Jordan DelFavero

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

Tamás Kiss, Ádám Nyúl‐Tóth, Priya Balasubramanian et al. · GeroScience · 2020 · 185 citations

Single Cell Sequencing, Medicine, Degenerative Pathology +8

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

Andriy Yabluchanskiy, Stefano Tarantini, Priya Balasubramanian et al. · GeroScience · 2020 · 113 citations · Full text

Neurodegenerative Diseases, Neurophysiology, Synaptic Transmission +12

Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging

Stefano Tarantini, Andriy Yabluchanskiy, Tamás Csípő et al. · GeroScience · 2019 · 101 citations · Full text

Alzheimer's Disease, Aging, Longevity +13

Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice

Stefano Tarantini, Priya Balasubramanian, Jordan DelFavero et al. · GeroScience · 2021 · 88 citations · Full text

Hematology, Pharmacology, Cell Death +5

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

Chetan Ahire, Ádám Nyúl‐Tóth, Jordan DelFavero et al. · Aging Cell · 2023 · 80 citations · Full text