Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain

Rafał Gulej, Ádám Nyúl‐Tóth, Chetan Ahire, +15

GeroScience

Neuro-oncologyHealth SciencesGliomaCell DeathMouse Brain +8

Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors

Rafał Gulej, Ádám Nyúl‐Tóth, Boglárka Csík, +11

GeroScience

InflammationAgingYoung Blood FactorsMedicineImmunology +11

Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax

Janet Faakye, Ádám Nyúl‐Tóth, Mihaly Muranyi, +12

GeroScience

AgingLongevityMedicineNovel ApproachCell Death +9

Endothelial deficiency of insulin‐like growth factor‐1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype

Rafał Gulej, Boglárka Csík, Janet Faakye, +9

Microcirculation

Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain

Rafał Gulej, Ádám Nyúl‐Tóth, Boglárka Csík, +12

GeroScience

Blood–brain BarrierMedicineImmunologyHeterochronic ParabiosisVascular Biology +11

Persisting blood–brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment

Roland Patai, Boglárka Csík, Ádám Nyúl‐Tóth, +10

GeroScience

Novel intravital approaches to quantify deep vascular structure and perfusion in the aging mouse brain using ultrasound localization microscopy (ULM)

Ádám Nyúl‐Tóth, Sharon Negri, Madison Sanford, +19

Journal of Cerebral Blood Flow & Metabolism

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Boglárka Csík, Ádám Nyúl‐Tóth, Rafał Gulej, +18

Aging Cell

Imaging the time course, morphology, neuronal tissue compression, and resolution of cerebral microhemorrhages in mice using intravital two-photon microscopy: insights into arteriolar, capillary, and venular origin

Janet Faakye, Ádám Nyúl‐Tóth, Rafał Gulej, +10

GeroScience

Tissue ImagingEngineeringNeurophysiologyMicroscopyBiomedical Imaging +11

Transcriptomic profiling of senescence effects on blood–brain barrier-related gene expression in brain capillary endothelial cells in a mouse model of paclitaxel-induced chemobrain

Roland Patai, Tamás Kiss, Rafał Gulej, +11

GeroScience