John Roderick

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Chu‐Biao Xue, Matthew E. Voss, David J. Nelson et al. · Journal of Medicinal Chemistry · 2001 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists

Chu‐Biao Xue, John Wityak, Thais M. Sielecki et al. · Journal of Medicinal Chemistry · 1997 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

Chu‐Biao Xue, Xiaohua He, John Roderick et al. · Journal of Medicinal Chemistry · 1998 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Chu‐Biao Xue, Xiaohua He, Ronald L. Corbett et al. · Journal of Medicinal Chemistry · 2001 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)

James J.‐W. Duan, Zhonghui Lu, Chu‐Biao Xue et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7